Direct evidence of the multidimensionality of the free-energy landscapes of proteins revealed by mechanical probes

Author(s): Zu Thur Yew, Michael Schlierf, Matthias Rief, and Emanuele Paci
The study of mechanical unfolding, through the combined efforts of atomic force microscopy and simulation, is yielding fresh insights into the free-energy landscapes of proteins. Thus far, experiments have been mostly analyzed with one-dimensional models of the free-energy landscape. We show that as…
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[Phys. Rev. E 81, 031923] Published Tue Mar 30, 2010